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This symposium highlights the work of the Global Health Research Center of Central Asia (GHRCCA), presenting a number of multi-level evidence-based HIV interventions conducted among key populations in Kazakhstan in Central Asia. These include:1) Project Renaissance, a couple-based intervention to reduce HIV risks and overdose; 2) Project Nova, a combination HIV prevention and microfinance intervention for sex workers to reduce sexual and drug-related risks for HIV and STIs; 3) UNI Project, a multi-site study designed to increase the number of men who have sex with men (MSM) and other sexual minority men engaged in the HIV care continuum; and 4) Project Bridge, a multisite study on integration of harm reduction and HIV services and differentiation of care to improve the HIV treatment cascade among PWID. The symposium participants will discuss the success of these interventions from efficacy to implementation and lessons learned in over ten years of GHRCCA’s work in the region.

Introduction: Scope of the HIV epidemic in Central Asia
A randomized controlled trial of a couple-based HIV and overdose prevention intervention for PWID in Kazakhstan: Project Renaissance
Louisa Gilbert, Columbia University, United States
A randomized controlled trial of a combination microfinance and HIV prevention intervention for FSW who use drugs in Kazakhstan: Project Nova
Assel Terlikbayeva, Global Health Research Center of Central Asia, Kazakhstan
Differentiation of HIV services for PWID in harm reduction programs in three cities in Kazakhstan: Project Bridge
Nabila El-Bassel, Columbia University, United States
Using social media and social networks to increase access to HIV care among MSM in three cities in Kazakhstan: Project UNI
Elwin Wu, Columbia University, United States
The process of contextually adapting evidence-based HIV interventions to meet the needs of key populations in Kazakhstan: examples from Nova and Bridge
Tara McCrimmon, Columbia University, United States
Innovative strategies to implement and sustain evidence-based multi-level HIV interventions: examples from Renaissance and Bridge
Timothy Hunt, Columbia University, United States