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The major barrier to a cure for HIV or long-term remission off Antiretroviral therapy (ART) is the persistence of latently infected cells. Persistence occurs because of infection of long-lived cells or through clonal expansion of infected cells. Understanding how HIV persists is critical to developing new strategies for elimination. These include strategies to reverse latency through activation to allow for immune recognition. Alternative approaches include permanent silencing of HIV expression through inhibitors of mammalian target of rapamycin (mTOR) function or gene silencing approaches.

16:30
WESY0901
Introduction
16:34
WESY0902
Introductory comments
Maureen Goodenow, NIH Office of AIDS Research, United States
16:39
WESY0903
Understanding HIV persistence – do defective viruses matter?
Ya-Chi Ho, Yale University School of Medicine, United States
16:56
WESY0904
Low level transcription on ART – implications for latency elimination
Steve Yukl, University of California, United States
Slides
17:13
WESY0905
TLR agonists and latency reversal: can they both shock and kill?
Martin Tolstrup, Aarhus University, Denmark
17:30
WESY0906
Block and lock using gene silencing
Anthony Kelleher, The University of New South Wales (UNSW), Australia
Slides
17:47
WESY0907
Understanding community participation in cure studies: what scientists need to know
Cipriano Martinez, NAPWHA, Australia
Slides
17:56
WESY0908
Wrap-up
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